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Article

Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents

29 Apr 2009

Abstract excerpt

The CYP17A1 gene is the qualitative regulator of steroidogenesis. Depending on the presence or absence of CYP17 activities mineralocorticoids, glucocorticoids or adrenal androgens are produced. The expression of the CYP17A1 gene is tissue as well as species-specific. In contrast to humans, adrenals of rodents do not express the CYP17A1 gene and have therefore no P450c17 enzyme for cortisol production, but produce...

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PMID: 19403566
DOI: 10.1677/joe-08-0353

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