Article
The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad.
Endocrinology - 1 Aug 2006
Couse John F, Yates Mariana M, Rodriguez Karina F, Johnson Jo Anne, Poirier Donald, Korach Kenneth S
Abstract excerpt
The predisposition of the testis and ovary to primarily synthesize testosterone (T) and estradiol (E2), respectively, is due to gonadal-specific cell types that differentially express the various hydroxysteroid (17beta) dehydrogenase (HSD17B) isoforms. In testes, Leydig cells rely on LH stimulation to maintain expression of the type 3 (HSD17B3) isoform, which specifically converts androstenedione to T. In...
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