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Prolactin Receptor-Associated Protein/17β-Hydroxysteroid Dehydrogenase Type 7 Gene (<i>Hsd17b7</i>) Plays a Crucial Role in Embryonic Development and Fetal Survival

31 Jul 2008

Abstract excerpt

Our laboratory has previously cloned and purified a protein named PRAP (prolactin receptor-associated protein) that was shown to be a novel 17beta-hydroxysteroid dehydrogenase (HSD) enzyme with dual activity. This enzyme, renamed HSD17B7 or PRAP/17beta-HSD7, converts estrone to estradiol and is also involved in cholesterol biosynthesis. The major site of its expression is the corpus luteum of a great number of...

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PMID: 18669642
DOI: 10.1210/me.2008-0165

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