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Article

Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse.

Journal of translational medicine - 15 Oct 2021

Secchi Christian, Belli Martina, Harrison Tracy N H, Swift Joseph, Ko CheMyong, Duleba Antoni J, Stupack Dwayne, Chang R Jeffrey, Shimasaki Shunichi

Abstract excerpt

BACKGROUND: In the ovarian follicle, the Theca Cells (TCs) have two main functions: preserving morphological integrity and, importantly, secreting steroid androgen hormones. TCs express the essential enzyme 17α-hydroxylase/17,20-desmolase (CYP17), which permits the conversion of pregnenolone and progesterone into androgens. Dysregulation of CYP17 enzyme activity due to an intrinsic ovarian defect is hypothesized...

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Identifiers

PMID: 34654452
DOI: 10.1186/s12967-021-03103-x
PMCID: PMC8520195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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