Sex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in mice.

doi:10.1152/physiolgenomics.00044.2008

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Article

Sex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in mice.

Physiological genomics - 12 Nov 2008

Herrera Victoria L M, Decano Julius L, Bagamasbad Pia, Kufahl Timothy, Steffen Martin, Ruiz-Opazo Nelson

Abstract excerpt

Aside from abnormal angiogenesis, dual endothelin-1/VEGF signal peptide-activated receptor deficiency (DEspR(-/-)) results in aberrant neuroepithelium and neural tube differentiation, thus elucidating DEspR's role in neurogenesis. With the emerging importance of neurogenesis in adulthood, we tested the hypothesis that nonembryonic-lethal DEspR haploinsufficiency (DEspR(+/-)) perturbs neuronal homeostasis, thereby...

Topics

Animals
Autophagy
Behavior, Animal
Cognition Disorders
Female
Hippocampus
Male
Maze Learning
Mice
Mice, Inbred C57BL
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neurons

Receptors, Angiotensin

Receptors, Endothelin

Reverse Transcriptase Polymerase Chain Reaction

Sex Factors

Social Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 18780760
DOI: 10.1152/physiolgenomics.00044.2008
PMCID: PMC2585022

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