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Article

Sex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in mice.

Physiological genomics - 12 Nov 2008

Herrera Victoria L M, Decano Julius L, Bagamasbad Pia, Kufahl Timothy, Steffen Martin, Ruiz-Opazo Nelson

Abstract excerpt

Aside from abnormal angiogenesis, dual endothelin-1/VEGF signal peptide-activated receptor deficiency (DEspR(-/-)) results in aberrant neuroepithelium and neural tube differentiation, thus elucidating DEspR's role in neurogenesis. With the emerging importance of neurogenesis in adulthood, we tested the hypothesis that nonembryonic-lethal DEspR haploinsufficiency (DEspR(+/-)) perturbs neuronal homeostasis, thereby...

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Identifiers

PMID: 18780760
DOI: 10.1152/physiolgenomics.00044.2008
PMCID: PMC2585022

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Source receipt: pubmed, retrieved 7 Sept 2026.

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