Article
N- and O-glycans are not directly involved in the oligomerization and apical sorting of GPI proteins.
Traffic (Copenhagen, Denmark) - 1 Dec 2008
Catino Maria A, Paladino Simona, Tivodar Simona, Pocard Thomas, Zurzolo Chiara
Abstract excerpt
Oligomerization of glycosyl-phosphatidylinositol-anchored proteins (GPI-APs) into high molecular weight complexes is an essential step for their apical sorting in polarized epithelial cells. However, the mechanism by which apical GPI-APs oligomerize is still unclear. To investigate the possible role of N- and O-glycosylation, we have analysed the behaviour of two glycosylated GPI-anchored apical proteins, p75GPI...
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