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Article

Mannosamine, a novel inhibitor of glycosylphosphatidylinositol incorporation into proteins.

The EMBO journal - 1 Aug 1991

Lisanti M P, Field M C, Caras I W, Menon A K, Rodriguez-Boulan E

Abstract excerpt

Mannosamine (2-amino-2-deoxy D-mannose) is shown here to block the incorporation of glycosylphosphatidylinositol (GPI) into GPI-anchored proteins. The amino sugar drastically reduced the surface expression of a recombinant GPI-anchored protein in polarized MDCK cells, converted this apical membrane-bound protein to an unpolarized secretory product and blocked the expression of endogenous GPI-anchored proteins....

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Identifiers

PMID: 1829673
DOI: 10.1002/j.1460-2075.1991.tb07726.x
PMCID: PMC452876

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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