Mannosamine, a novel inhibitor of glycosylphosphatidylinositol incorporation into proteins.

doi:10.1002/j.1460-2075.1991.tb07726.x

Back to search

Article

Mannosamine, a novel inhibitor of glycosylphosphatidylinositol incorporation into proteins.

The EMBO journal - 1 Aug 1991

Lisanti M P, Field M C, Caras I W, Menon A K, Rodriguez-Boulan E

Abstract excerpt

Mannosamine (2-amino-2-deoxy D-mannose) is shown here to block the incorporation of glycosylphosphatidylinositol (GPI) into GPI-anchored proteins. The amino sugar drastically reduced the surface expression of a recombinant GPI-anchored protein in polarized MDCK cells, converted this apical membra...

Topics

Animals
Cell Line
Dogs
Glycolipids
Glycosylphosphatidylinositols
Hexosamines
Mutation
Phosphatidylinositols
Precipitin Tests
Protozoan Proteins
Trypanosoma brucei brucei

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.