Article
Manipulation of the peptide-binding specificity of an RNA in a rational manner by combinations of specificity-altering mutations.
Nucleic acids symposium series (2004) - 1 Jan 2008
Harada Kazuo, Sugaya Maki, Nishimura Futoshi, Katoh Akira
Abstract excerpt
In this study, the potential to manipulate the peptide-binding specificity of an RNA in a rational manner was investigated. First, variants of the Rev-response element (RRE) RNA with different specificities towards the natural binding partner, Rev, and two RRE-binding aptamers, the RSG-1.2 and K1 peptides, were identified. Next, hybrid RRE mutants with combinations of two sets of specificity-altering...
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