Article
Molding a peptide into an RNA site by in vivo peptide evolution.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 1997
Harada K, Martin S S, Tan R, Frankel A D
Abstract excerpt
Short peptides corresponding to the arginine-rich domains of several RNA-binding proteins are able to bind to their specific RNA sites with high affinities and specificities. In the case of the HIV-1 Rev-Rev response element (RRE) complex, the peptide forms a single alpha-helix that binds deeply in a widened, distorted RNA major groove and makes a substantial set of base-specific and backbone contacts. Using a...
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