Article
Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population.
Clinical science (London, England : 1979) - 1 Nov 2008
Linsel-Nitschke Patrick, Götz Anika, Medack Anja, König Inke R, Bruse Petra, Lieb Wolfgang, Mayer Björn, Stark Klaus, Hengstenberg Christian, Fischer Marcus, Baessler Andrea, Ziegler Andreas, Schunkert Heribert, Erdmann Jeanette
Abstract excerpt
Genetic variation in the genes ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) and stroke in Icelandic and Scottish populations. Both genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene B mediators, possibly providing a link between MI and...
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