Article
Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene.
Hormones and behavior - 1 Dec 1997
Wersinger S R, Sannen K, Villalba C, Lubahn D B, Rissman E F, De Vries G J
Abstract excerpt
Masculine sexual behavior is regulated by testosterone (T). However, T can be metabolized to form estrogens or other androgens, which then activate their own receptors. We used knockout mice lacking a functional estrogen receptor alpha (ER alpha) gene to test the hypothesis that, following aromatization, T acts via the ER alpha to activate normal masculine sexual behavior. After gonadectomy and T replacement,...
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