Article

Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

2024-02-16

Abstract excerpt

In rodents, estrogens aromatized from androgens in the brain are essential for the development of male-typical behaviors. In many other vertebrates including humans and teleost fish, however, androgens facilitate these behaviors directly via the androgen receptor without aromatization into estrogens. Here we report that mutagenesis-derived male medaka fish lacking Cyp19a1b (a subtype of aromatase predominantly exp...

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Literature Corpus work: 10dfaaf9-5fb8-584a-844a-0f1d83fc7c91
DOI: 10.1101/2024.02.13.580203

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