Article
The COL5A3 and MMP9 genes interact in eczema susceptibility.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2018
Margaritte-Jeannin P, Babron M-C, Laprise C, Lavielle N, Sarnowski C, Brossard M, Moffatt M, Gagné-Ouellet V, Etcheto A, Lathrop M, Just J, Cookson W O, Bouzigon E, Demenais F, Dizier M-H
Abstract excerpt
BACKGROUND: Genetic studies of eczema have identified many genes, which explain only 14% of the heritability. Missing heritability may be partly due to ignored gene-gene (G-G) interactions. OBJECTIVE: Our aim was to detect new interacting genes involved in eczema. METHODS: The search for G-G interaction in eczema was conducted using a two-step approach, which included as a first step, a biological selection of...
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