Article
PolA1, a putative DNA polymerase I, is coexpressed with PerR and contributes to peroxide stress defenses of group A Streptococcus.
Journal of bacteriology - 1 Feb 2013
Toukoki Chadia, Gryllos Ioannis
Abstract excerpt
The peroxide stress response regulator PerR coordinates the oxidative-stress defenses of group A Streptococcus (GAS). We now show that PerR is expressed from an operon encoding a putative DNA polymerase I (PolA1), among other GAS products. A polA1 deletion mutant exhibited wild-type growth but showed reduced capacity to repair DNA damage caused by UV light or ciprofloxacin. Mutant bacteria were hypersensitive to...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Ciprofloxacin
- DNA Damage
- DNA Polymerase I
- Drug Resistance, Bacterial
- Gene Expression Regulation, Bacterial
- Genetic Variation
- Genome, Bacterial
- Hydrogen Peroxide
- Mutation
- Naphthoquinones
- Repressor Proteins
- Rifampin
- Streptococcus pyogenes
- Ultraviolet Rays