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Article

Genome-wide identification of genes required for fitness of group A Streptococcus in human blood.

Infection and immunity - 1 Mar 2013

Le Breton Yoann, Mistry Pragnesh, Valdes Kayla M, Quigley Jeffrey, Kumar Nikhil, Tettelin Hervé, McIver Kevin S

Abstract excerpt

The group A streptococcus (GAS) is a strict human pathogen responsible for a wide spectrum of diseases. Although GAS genome sequences are available, functional genomic analyses have been limited. We developed a mariner-based transposon, osKaR, designed to perform Transposon-Site Hybridization (TraSH) in GAS and successfully tested its use in several invasive serotypes. A complex osKaR mutant library in M1T1 GAS...

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Share to Chromosomes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Genetic Fitness

Share to Genome, Bacterial

Share to Hemolysin Proteins

Share to Mutagenesis, Insertional

Share to Streptococcus pyogenes

Source

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Identifiers

PMID: 23297387
DOI: 10.1128/IAI.00837-12
PMCID: PMC3584890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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