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Article

Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction.

American journal of human genetics - 1 Sept 2008

Ellouze Sami, Augustin Sébastien, Bouaita Aicha, Bonnet Crystel, Simonutti Manuel, Forster Valérie, Picaud Serge, Sahel Jose-Alain, Corral-Debrinski Marisol

Abstract excerpt

Mitochondrial diseases due to mutations in mitochondrial DNA can no longer be ignored in most medical areas. With prevalence certainly higher than one in 6000, they probably represent the most common form of metabolic disorders. Despite progress in identification of their molecular mechanisms, little has been done with regard to therapy. We have recently optimized the allotopic expression for the mitochondrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Optic Atrophy, Hereditary, Leber

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Source

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Identifiers

PMID: 18771762
DOI: 10.1016/j.ajhg.2008.08.013
PMCID: PMC2556433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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