Article
The pathological mechanisms and novel therapeutics for Leber's hereditary optic neuropathy.
Journal of the Chinese Medical Association : JCMA - 1 Jun 2023
Yang Yi-Ping, Foustine Shania, Hsiao Yu-Jer, Tsai En-Tung, Tsai Fu-Ting, Wang Chia-Lin, Ko Yu-Ling, Tai Hsiao-Yun, Tsai Yi-Ching, Yang Chang-Hao, Fu Yun-Ju, Wang An-Guor, Chien Yueh
Abstract excerpt
Optic neuropathies were estimated to affect 115 in 100,000 population in 2018. Leber's Hereditary Optic Neuropathy (LHON) as one of such optic neuropathy diseases that was first identified in 1871 and can be defined as a hereditary mitochondrial disease. LHON is associated with three mtDNA point mutations which are G11778A, T14484, and G3460A that affect the NADH dehydrogenase subunits of 4, 6, and 1,...
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