Systematic review of Leber's hereditary optic neuropathy - Clinical diagnosis, genetics overview and current concepts of treatment.

Abstract excerpt

Leber hereditary optic neuropathy (LHON) is the most common mitochondrial disorder, typically causing substantial, often permanent, central vision loss in young adults. It manifests as a subacute optic neuropathy, frequently progressing sequentially in both eyes, due to selective degeneration of retinal ganglion cells (RGCs). The condition is primarily associated with three mitochondrial DNA (mtDNA) point...

Topics

• Humans
• Optic Atrophy, Hereditary, Leber
• Genetic Therapy
• DNA, Mitochondrial
• Gene Therapy Agents
• Mutation
• Ubiquinone
• Antioxidants
• Retinal Ganglion Cells