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Article

MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber's hereditary optic neuropathy.

Science China. Life sciences - 1 Nov 2024

Wang Rui, Bao Feixiang, Lu Manjiao, Jia Xiaoyun, Xiao Jiahui, Wu Yi, Zhang Qingjiong, Liu Xingguo

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is a debilitating mitochondrial disease associated with mutations in mitochondrial DNA (mtDNA). Unfortunately, the available treatment options for LHON patients are limited due to challenges in mitochondrial replacement. In our study, we reprogramming LHON urine cells into induced pluripotent stem cells (iPSCs) and differentiating them into neural progenitor cells (NPCs)...

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Identifiers

PMID: 39134891
DOI: 10.1007/s11427-024-2647-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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