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Mesenchymal stem cell mitochondrial transfer effectively protects Leber's Hereditary Optic Neuropathy (LHON) mutant cells from mitochondrial damage.

Acta histochemica - 1 Jun 2026

Nair Aswathy P, Janaki P Aishwarya, Gopalarethinam Janani, Kumar B Abishek, Vellingiri Balachandar, Subramaniam Mohana Devi

Abstract excerpt

Leber's Hereditary Optic Neuropathy (LHON) is the most prevalent mitochondrial inherited disorder, primarily caused by primary mitochondrial mutations. Clinically, LHON is characterized by degeneration of optic nerves that leads to acute or subacute sudden or painless central vision loss. Currently no effective treatment has been established for LHON. Recent studies have highlighted the significance of...

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Apoptosis
Coculture Techniques
Membrane Potential, Mitochondrial
Mesenchymal Stem Cells
Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Optic Atrophy, Hereditary, Leber

Reactive Oxygen Species

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PMID: 41764869
DOI: 10.1016/j.acthis.2026.152331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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