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Article

Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder.

The international journal of neuropsychopharmacology - 1 Feb 2009

Hayashi Akiko, Kasahara Takaoki, Kametani Mizue, Toyota Tomoko, Yoshikawa Takeo, Kato Tadafumi

Abstract excerpt

Impaired endoplasmic reticulum (ER) stress response has been suggested as a possible pathophysiological mechanism of bipolar disorder (BD). The expression of ER stress-related genes, spliced form or unspliced form of XBP1, GRP78 (HSPA5), GRP94 (HSP90B1), CHOP (DDIT3), and calreticulin (CALR), were examined in lymphoblastoid cells derived from 59 patients with BD and 59 age- and sex-matched control subjects. Basal...

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Source

Identifiers

PMID: 18771604
DOI: 10.1017/S1461145708009358

Genes

XBP1
CALR
DDIT3
HSPA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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