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Article

Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme

3 Sept 2008

Abstract excerpt

Alterations in the signal transduction pathways are key mechanisms in the pathogenesis of de novo glioblastoma multiforme (GBM), which are also involved in the resistance to chemo- and radiotherapy. Here, we analyzed the methylation status and mRNA expression of suppressor of cytokine signaling (SOCS)1-2-3, 3 of the most important inhibitory molecules of the signal transduction circuitry, in 46 GBM specimens. The...

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PMID: 18770864
DOI: 10.1002/ijc.23805

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