SOCS proteins and their roles in the development of glioblastoma (Review)

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common type of primary brain tumor in adults. GBM is characterized by a high degree of malignancy and aggressiveness, as well as high morbidity and mortality rates. GBM is currently treatable via surgical resection, chemotherapy and radiotherapy, but the prognosis of patients with GBM is poor. The suppressor of cytokine signaling (SOCS) protein family comprises eight...

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• Cancer Mechanisms and Therapy
• Cytokine Signaling Pathways and Interactions
• interferon and immune responses