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Article

Methylation status of the SOCS3 gene in human malignant melanomas

1 Mar 2007

Abstract excerpt

The suppressors of cytokine signaling (SOCS) family inhibits not only Janus kinase (JAK)/signal transducers and activators of transcription (STAT) but also focal adhesion kinase (FAK) signaling pathways, and has tumor suppressor activity. Aberrant methylation in the promoter region of the SOCS3 gene frequently occurs in several types of human malignancy, and its transcriptional silencing is associated with...

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PMID: 17273770
DOI: 10.3892/ijo.30.3.689

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Methylation status of the SOCS3 gene in human malignant melanomasPMID 17273770Read ↗

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