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Article

Lentivirus Vector Can Be Readministered to Nasal Epithelia without Blocking Immune Responses

4 Sept 2008

Abstract excerpt

For many envisioned applications of lentivirus vectors as tools in respiratory biology and therapeutic gene delivery, the efficiency of gene transfer must be improved. We previously demonstrated stable, persistent (>11 months) in vivo expression following a single application of a feline immunodeficiency virus (FIV)-based lentivirus vector (GP64-FIV) to murine nasal epithelia. Here we investigate the efficacy of...

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PMID: 18768988
DOI: 10.1128/jvi.00227-08

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