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Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages

28 Dec 2009

Abstract excerpt

Directed gene transfer into specific cell lineages in vivo is an attractive approach for both modulating gene expression and correcting inherited mutations such as emphysema caused by human alpha1 antitrypsin (hAAT) deficiency. However, somatic tissues are mainly comprised of heterogeneous, differentiated cell lineages that can be short lived and difficult to specifically transfect. Here, we describe an...

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PMID: 20038801
DOI: 10.1172/jci36666

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