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Article

Successful transgene expression with serial doses of aerosolized rAAV2 vectors in rhesus macaques

11 Oct 2003

Abstract excerpt

Bronchoscopic microspraying of recombinant adeno-associated viral (rAAV) vectors targets high doses of vector directly to pulmonary epithelium. Single-dose endobronchial gene therapy trials have been accomplished in cystic fibrosis patients; however, repeated dosing strategies are likely essential for lifetime correction. These studies address whether serial redosing with rAAV2 vectors results in an antiserotypic...

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PMID: 14664794
DOI: 10.1016/j.ymthe.2003.08.015

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