Article

Chronic lung infection does not impair lentiviral vector gene transfer in a cystic fibrosis rat model

2026-06-14

Abstract excerpt

<title>Abstract</title> <p> Genetic therapies offer a promising strategy for treating cystic fibrosis (CF) lung disease, particularly for individuals with modulator–ineligible genotypes. However, clinical translation has been slower than anticipated. While gene therapy candidates often demonstrate efficacy in preclinical studies, all products trialled to date have failed to progress beyond Phase I/II, potentiall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0713759-3db5-5d1d-9895-fd11b12e8e94
DOI: 10.21203/rs.3.rs-9936876/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chronic lung infection does not impair lentiviral vector gene transfer in a cystic fibrosis rat modelDOI 10.21203/rs.3.rs-9936876/v1Read

Cystic fibrosis gene therapy: a mutation-independent treatment.Semantic proximity Read

Moving forward: cystic fibrosis gene therapySemantic proximity Read

Genetic therapies for cystic fibrosis lung diseaseSemantic proximity Read

Advances in Cell and Gene-based Therapies for Cystic Fibrosis Lung DiseaseSemantic proximity Read

Lentiviral vector gene therapy and CFTR modulators show comparable effectiveness in cystic fibrosis rat airway modelsSemantic proximity Read

Lentiviral vectors transduce lung stem cells without disrupting plasticitySemantic proximity Read

A chronic <i>Pseudomonas aeruginosa</i> mouse lung infection modeling the pathophysiology and inflammation of human cystic fibrosisSemantic proximity Read

Lentiviral vectors transduce lung stem cells without disrupting plasticitySemantic proximity Read

Viral Vectors, Animal Models, and Cellular Targets for Gene Therapy of Cystic Fibrosis Lung DiseaseSemantic proximity Read

Cystic fibrosis gene therapy: successes, failures and hopes for the futureSemantic proximity Read

Delivery of genes into the CF airwaySemantic proximity Read

Single‐dose lentiviral gene transfer for lifetime airway gene expressionSemantic proximity Read