Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

First evidence of genetic association between AKT2 and polycystic ovary syndrome.

Diabetes care - 1 Dec 2008

Goodarzi Mark O, Jones Michelle R, Chen Yii-Der I, Azziz Ricardo

Abstract excerpt

OBJECTIVE: Insulin resistance has been reported in up to 70% of women with polycystic ovary syndrome (PCOS). Physiologic and genetic data currently implicate post-insulin receptor signaling defects in substrates such as glycogen synthase kinase 3beta (GSK3beta). The AKT2 gene was chosen as a candidate for PCOS because its product affects glucose metabolism and mitogenic signaling, interacts with GSK3beta, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Genetic Predisposition to Disease
Share to Glycogen Synthase Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3 beta

Share to Haplotypes

Share to Polycystic Ovary Syndrome

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 18768676
DOI: 10.2337/dc08-0532
PMCID: PMC2584182

Genes

AKT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

First evidence of genetic association between AKT2 and polycystic ovary syndrome.PMID 18768676Read ↗

Association between AKT2 gene polymorphism and polycystic ovary syndrome: a case-control study.Semantic proximity Read ↗

Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome.Semantic proximity Read ↗

Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes.Semantic proximity Read ↗

Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review.Semantic proximity Read ↗

Contribution of the Akt2 gene to type 2 diabetes in the Chinese Han population.Semantic proximity Read ↗

Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study.Semantic proximity Read ↗

Variation in Akt protein kinases in human populations.Semantic proximity Read ↗

Akt2 Gene common allelic variants in insulin resistance and the metabolic syndrome.Semantic proximity Read ↗

Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact?Semantic proximity Read ↗

Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndromeSemantic proximity Read ↗

Phenotype and genotype in polycystic ovary syndrome.Semantic proximity Read ↗

Molecular progress in infertility: polycystic ovary syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.