Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2008

Margulis Vitaly, Lin Jie, Yang Hushan, Wang Wei, Wood Christopher G, Wu Xifeng

Abstract excerpt

Alterations in DNA repair genes have been shown to cause a reduction in host DNA repair capacity and may influence host susceptibility to carcinogenesis. The double-strand break repair is a major DNA-repair pathway. This study tested the hypothesis that common sequence variants of the double-strand break pathway genes predispose susceptible individuals to an increased risk for renal cell carcinoma. Toward this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Renal Cell
Share to Chi-Square Distribution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Incidence

Share to Kidney Neoplasms

Share to Regression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 18768505
DOI: 10.1158/1055-9965.EPI-08-0259
PMCID: PMC2581835

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway.PMID 18768505Read ↗

Genetic variations in base excision repair pathway and risk of bladder cancer: a case-control study in the United States.Semantic proximity Read ↗

Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.Semantic proximity Read ↗

Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.Semantic proximity Read ↗

Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.Semantic proximity Read ↗

Complex association between ERCC2 gene polymorphisms, gender, smoking and the susceptibility to bladder cancer: a meta-analysis.Semantic proximity Read ↗

Case-control analysis of nucleotide excision repair pathway and the risk of renal cell carcinoma.Semantic proximity Read ↗

Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk.Semantic proximity Read ↗

Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.Semantic proximity Read ↗

Exosome component 1 cleaves single-stranded DNA and sensitizes kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitorSemantic proximity Read ↗

DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

Genetic variants in DNA repair pathways and risk of upper aerodigestive tract cancers: combined analysis of data from two genome-wide association studies in European populations.Semantic proximity Read ↗

Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.