Article
Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
American journal of human genetics - 1 Mar 2006
Wu Xifeng, Gu Jian, Grossman H Barton, Amos Christopher I, Etzel Carol, Huang Maosheng, Zhang Qing, Millikan Randal E, Lerner Seth, Dinney Colin P, Spitz Margaret R
Abstract excerpt
The candidate-gene approach in association studies of polygenic diseases has often yielded conflicting results. In this hospital-based case-control study with 696 white patients newly diagnosed with bladder cancer and 629 unaffected white controls, we applied a multigenic approach to examine the associations with bladder cancer risk of a comprehensive panel of 44 selected polymorphisms in two pathways, DNA repair...
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