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Article

Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors.

Genes, chromosomes & cancer - 1 Jan 2009

Sweeney Carol, Boucher Kenneth M, Samowitz Wade S, Wolff Roger K, Albertsen Hans, Curtin Karen, Caan Bette J, Slattery Martha L

Abstract excerpt

Our understanding of somatic alterations in colon cancer has evolved from a concept of a series of events taking place in a single sequence to a recognition of multiple pathways. An oncogenetic tree is a model intended to describe the pathways and sequence of somatic alterations in carcinogenesis without assuming that tumors will fall in mutually exclusive categories. We applied this model to data on colon tumor...

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Identifiers

PMID: 18767147
DOI: 10.1002/gcc.20614
PMCID: PMC3742107

Genes

APC
BRAF
MLH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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