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Exploring the Somatic Mutation Landscape of T4N0: A Comparative Perspective on Late Stage II and Stage III Colon Cancer.

Diseases of the colon and rectum - 1 Jul 2025

Otohinoyi David, Pavleszek Katherine E, Dooley Danielle Alexandra, Carr Brian T, Mabry Triston L, Hicks Chindo, Nfonsam Valentine N

Abstract excerpt

BACKGROUND: Among the facets of colon cancer pathogenesis is the survival paradox between T4N0 (stage II) colon cancer and anyTN1 (stage III) colon cancer. There are limited genomic studies investigating why a T4N0 disease is deemed worse than stage III colon cancer. OBJECTIVE: We demonstrate a multifaceted approach to unraveling the genomic intricacies of T4N0 colon cancer and how it differs from T123N0 and...

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Identifiers

PMID: 40192132
DOI: 10.1097/DCR.0000000000003721

Genes

DIDO1
ALMS1
CACNA1B

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