The complex genomic profile of <i>ETV6‐RUNX1</i> positive acute lymphoblastic leukemia highlights a recurrent deletion of <i>TBL1XR1</i>

Abstract excerpt

The ETV6-RUNX1 fusion is the molecular consequence of the t(12;21)(p13;q22) seen in approximately 25% of children with acute lymphoblastic leukemia (ALL). Studies have shown that the fusion alone is insufficient for the initiation of leukemia; additional genetic changes are required. Genomic profiling identified copy number alterations at high frequencies in these patients. Focal deletions of TBL1XR1 were...

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