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Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis.

Antimicrobial agents and chemotherapy - 1 May 2011

Malik Muhammad, Marks Kevin R, Mustaev Arkady, Zhao Xilin, Chavda Kalyan, Kerns Robert J, Drlica Karl

Abstract excerpt

Quinazolinediones (diones) are fluoroquinolone-like inhibitors of bacterial gyrase and DNA topoisomerase IV. To assess activity against mycobacteria, C-8-methoxy dione derivatives were compared with cognate fluoroquinolones by using cultured Mycobacterium smegmatis. Diones exhibited higher MIC values than fluoroquinolones; however, MICs for fluoroquinolone-resistant gyrA mutants, normalized to the MIC for...

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Identifiers

PMID: 21383100
DOI: 10.1128/AAC.00033-11
PMCID: PMC3088267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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