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Article

In vitro biological evaluation of novel broad-spectrum isothiazolone inhibitors of bacterial type II topoisomerases.

The Journal of antimicrobial chemotherapy - 1 Oct 2016

Charrier Cédric, Salisbury Anne-Marie, Savage Victoria J, Moyo Emmanuel, Forward Henry, Ooi Nicola, Cheung Jonathan, Metzger Richard, McGarry David, Walker Rolf, Cooper Ian R, Ratcliffe Andrew J, Stokes Neil R

Abstract excerpt

OBJECTIVES: To evaluate the in vitro biological properties of a novel class of isothiazolone inhibitors of the bacterial type II topoisomerases. METHODS: Inhibition of DNA gyrase and topoisomerase IV activity was assessed using DNA supercoiling and decatenation assays. MIC and MBC were determined according to CLSI guidelines. Antibacterial combinations were assessed using a two-dimensional chequerboard MIC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27353465
DOI: 10.1093/jac/dkw228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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