Article
Effect of genetic variability within 8q24 on aggressiveness patterns at diagnosis and familial status of prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2008
Cussenot Olivier, Azzouzi Abdel-Rahmène, Bantsimba-Malanda Gladys, Gaffory Cecile, Mangin Philippe, Cormier Luc, Fournier Georges, Valeri Antoine, Jouffe Lionel, Roupret Morgan, Fromont Gaelle, Sibony Mathilde, Comperat Eva, Cancel-Tassin Géraldine
Abstract excerpt
PURPOSE: Recently, two independent loci located at 8q24 that contribute to prostate cancer risk in men of European origin were identified. EXPERIMENTAL DESIGN: Using Bayesian probability network and logistic regression model, we searched for associations between 34 single-nucleotide polymorphisms (SNP) located at 8q24 and the aggressiveness patterns of prostate adenocarcinoma or familial history of cancers in 823...
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