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Article

Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal.

Molecular microbiology - 1 Nov 2008

Uchida Kaori, Furukohri Asako, Shinozaki Yutaka, Mori Tetsuya, Ogawara Daichi, Kanaya Shigehiko, Nohmi Takehiko, Maki Hisaji, Akiyama Masahiro

Abstract excerpt

Escherichia coli dinB encodes the specialized DNA polymerase DinB (Pol IV), which is induced as part of the SOS stress-response system and functions in translesion synthesis (TLS) to relieve the replicative Pol III that is stalled at DNA lesions. As the number of DinB molecules, even in unstressed cells, is greater than that required to accomplish TLS, it is thought that dinB plays some additional physiological...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18761688
DOI: 10.1111/j.1365-2958.2008.06423.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Overproduction of Escherichia coli DNA polymerase DinB (Pol IV) inhibits replication fork progression and is lethal.PMID 18761688Read ↗

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A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymeraseSemantic proximity Read ↗

An active site aromatic triad in Escherichia coli DNA Pol IV coordinates cell survival and mutagenesis in different DNA damaging agents.Semantic proximity Read ↗

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A ΔdinB mutation that sensitizes Escherichia coli to the lethal effects of UV- and X-radiation.Semantic proximity Read ↗

DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.Semantic proximity Read ↗

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