Article
Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.
Free radical biology & medicine - 1 Nov 2008
Vali Shireen, Chinta Shankar J, Peng Jun, Sultana Zeba, Singh Neetu, Sharma Purushottam, Sharada S, Andersen Julie K, Bharath M M Srinivas
Abstract excerpt
Dopaminergic neurodegeneration during Parkinson disease (PD) involves several pathways including proteasome inhibition, alpha-synuclein (alpha-syn) aggregation, mitochondrial dysfunction, and glutathione (GSH) depletion. We have utilized a systems biology approach and built a dynamic model to und...
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