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Article

Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease.

Neurochemistry international - 1 Apr 2006

Lehmensiek Vera, Tan Eva-Maria, Liebau Stefan, Lenk Thomas, Zettlmeisl Heinz, Schwarz Johannes, Storch Alexander

Abstract excerpt

6-Hydroxydopamine (6-OHDA) is widely used to produce animal models of Parkinson's disease (PD) by selectively destroying the nigro-striatal dopaminergic systems, but selective toxicity of 6-OHDA towards dopaminergic cells in vitro remains controversial. Mutant (A30P and A53T) alpha-synuclein isoforms cause increased vulnerability of cells towards various toxic insults and enhance dopamine transporter...

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Identifiers

PMID: 16406146
DOI: 10.1016/j.neuint.2005.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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