Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait.

doi:10.1016/j.ajhg.2008.08.002

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Article

Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait.

American journal of human genetics - 1 Sept 2008

Huyghe Jeroen R, Van Laer Lut, Hendrickx Jan-Jaap, Fransen Erik, Demeester Kelly, Topsakal Vedat, Kunst Sylvia, Manninen Minna, Jensen Mona, Bonaconsa Amanda, Mazzoli Manuela, Baur Manuela, Hannula Samuli, Mäki-Torkko Elina, Espeso Angeles, Van Eyken Els, Flaquer Antonia, Becker Christian, Stephens Dafydd, Sorri Martti, Orzan Eva, Bille Michael, Parving Agnete, Pyykkö Ilmari, Cremers Cor W R J, Kremer Hannie, Van de Heyning Paul H, Wienker Thomas F, Nürnberg Peter, Pfister Markus, Van Camp Guy

Abstract excerpt

Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component...

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Identifiers

PMID: 18760390
DOI: 10.1016/j.ajhg.2008.08.002
PMCID: PMC2556434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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