Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.

doi:10.1038/ejhg.2014.56

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Article

Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.

European journal of human genetics : EJHG - 1 Jan 2015

Fransen Erik, Bonneux Sarah, Corneveaux Jason J, Schrauwen Isabelle, Di Berardino Federica, White Cory H, Ohmen Jeffrey D, Van de Heyning Paul, Ambrosetti Umberto, Huentelman Matthew J, Van Camp Guy, Friedman Rick A

Abstract excerpt

We performed a genome-wide association study (GWAS) to identify the genes responsible for age-related hearing impairment (ARHI), the most common form of hearing impairment in the elderly. Analysis of common variants, with and without adjustment for stratification and environmental covariates, rare variants and interactions, as well as gene-set enrichment analysis, showed no variants with genome-wide significance....

Topics

Age Factors
Aged
Aged, 80 and over
Computational Biology
Databases, Genetic
Environment
Epistasis, Genetic
Female
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Hearing Loss

Humans

Male

Multifactorial Inheritance

Phenotype

Polymorphism, Single Nucleotide

Quantitative Trait, Heritable

Source

Open in PubMed Open full text

Identifiers

PMID: 24939585
DOI: 10.1038/ejhg.2014.56
PMCID: PMC4266741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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