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Age-Related Hearing Impairment: Genome and Blood Methylome Data Integration Reveals Candidate Epigenetic Biomarkers.

Omics : a journal of integrative biology - 1 Dec 2024

Yu Jie, Zhu Jingjing, Zhong Hua, Zhang Zicheng, Liu Jiawen, Lin Xin, Zeng Guanghua, Zhang Min, Wu Chong, Deng Youping, Sun Yanfa, Wu Lang

Abstract excerpt

Age-related hearing impairment (ARHI) is a major planetary health burden that is in need of precision medicine for prevention, diagnosis, and treatment. The present study was set out to identify candidate epigenetic markers for ARHI. Associations of genetically predicted DNA methylation levels with ARHI risk were evaluated using two sets of blood DNA methylation genetic prediction models in 147,997 cases and...

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Biomarkers
Case-Control Studies
CpG Islands
DNA Methylation
Epigenesis, Genetic

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PMID: 39585213
DOI: 10.1089/omi.2024.0172

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