Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation.

Abstract excerpt

Diabetes is a major contributing factor in cataract development. In animal models where cataracts develop within days or weeks of diabetes it is well established that osmotic stress from the accumulation of sorbitol leads to cataract development. This mechanism might explain the rare cases of acute cataract sometimes found in patients with uncontrolled sustained hyperglycemia but cannot account for the vast...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aldehyde Reductase
• Share to Diabetes Mellitus, Experimental