Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.

doi:10.1073/pnas.92.7.2780

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Article

Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 1995

Lee A Y, Chung S K, Chung S S

Abstract excerpt

Aldose reductase (AR) has been implicated in the etiology of diabetic cataract, as well as in other complications. However, the role of AR in these complications remains controversial because the strongest supporting evidence is drawn from the use of AR inhibitors for which specificity in vivo ca...

Topics

Aldehyde Reductase
Animals
Blotting, Southern
Cataract
Crosses, Genetic
DNA, Complementary
Diabetes Mellitus, Experimental
Diabetic Retinopathy
Female
Galactitol
Galactose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Galactosemias

Genotype

Humans

Lens, Crystalline

Male

Mice

Mice, Inbred BALB C

Source

Open in PubMed Open full text

Identifiers

PMID: 7708723
DOI: 10.1073/pnas.92.7.2780
PMCID: PMC42302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7708723-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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