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Article

Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice.

The Journal of biological chemistry - 31 Aug 2007

Lassen Natalie, Bateman J Bronwyn, Estey Tia, Kuszak Jer R, Nees David W, Piatigorsky Joram, Duester Gregg, Day Brian J, Huang Jie, Hines Lisa M, Vasiliou Vasilis

Abstract excerpt

ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cornea but undetectable in the lens, and ALDH1A1 is present at lower (catalytic) levels in the cornea and lens. To test the hypothesis that ALDH3A1 and ALDH1A1 protect the anterior segment of the eye against environmentally induced oxidative damage, Aldh1a1(-/-)/Aldh3a1(-/-) double knock-out and Aldh1a1(-/-) and Aldh3a1(-/-) single knock-out mice were...

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Identifiers

PMID: 17567582
DOI: 10.1074/jbc.M702076200
PMCID: PMC2253645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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