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Article

Increasing susceptibility to oxidative stress by cataract-causing crystallin mutations.

International journal of biological macromolecules - 1 Mar 2018

Zhao Wei-Jie, Yan Yong-Bin

Abstract excerpt

Cataract, a crystallin protein aggregation disease, is the leading cause of human blindness worldwide. Congenital cataract may be induced by many factors and genetic disorders accounts for about half of the cases. Inherited mutations can promote cataract formation by affecting crystallin structure, solubility, stability, protein interactions and aggregatory propensity. In this research, we investigated the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29222017
DOI: 10.1016/j.ijbiomac.2017.12.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increasing susceptibility to oxidative stress by cataract-causing crystallin mutations.PMID 29222017Read ↗

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The impact of Hydrogen peroxide on structure, stability and functional properties of Human R12C mutant αA-crystallin: The imperative insights into pathomechanism of the associated congenital cataract incidence.Semantic proximity Read ↗

Protein Aggregation and Cataract: Role of Age-Related Modifications and Mutations in α-Crystallins.Semantic proximity Read ↗

Cataract-related variant R114C increases βA3-crystallin susceptibility to environmental stresses by disrupting the protein senior structure.Semantic proximity Read ↗

A novel cataract-related mutation R10P in γA-crystallin increases susceptibility to thermal shock and ultraviolet radiation of γA-crystallin.Semantic proximity Read ↗

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A novel mutation impairing the tertiary structure and stability of γC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens.Semantic proximity Read ↗

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