Article
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor.
Cancer research - 15 Dec 2005
Fujimoto Nobukazu, Wislez Marie, Zhang Jie, Iwanaga Kentaro, Dackor Jennifer, Hanna Amy E, Kalyankrishna Shailaja, Cody Dianna D, Price Roger E, Sato Mitsuo, Shay Jerry W, Minna John D, Peyton Michael, Tang Ximing, Massarelli Erminia, Herbst Roy, Threadgill David W, Wistuba Ignacio I, Kurie Jonathan M
Abstract excerpt
Recent findings in tumor biopsies from lung adenocarcinoma patients suggest that somatic mutations in the genes encoding epidermal growth factor receptor (EGFR) and Kirsten ras (KRAS) confer sensitivity and resistance, respectively, to EGFR inhibition. Here, we provide evidence that these genetic mutations are not sufficient to modulate the biological response of lung adenocarcinoma cells to EGFR inhibition. We...
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