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Article

Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity.

Nature medicine - 1 Sept 2008

Ting Li-Min, Gissot Mathieu, Coppi Alida, Sinnis Photini, Kim Kami

Abstract excerpt

Malaria continues to devastate sub-Saharan Africa owing to the emergence of drug resistance to established antimalarials and to the lack of an efficacious vaccine. Plasmodium species have a unique streamlined purine pathway in which the dual specificity enzyme purine nucleoside phosphorylase (PNP...

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Source

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Identifiers

PMID: 18758447
DOI: 10.1038/nm.1867
PMCID: PMC3937818

Genes

PNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18758447-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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