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Article

Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity.

Nature medicine - 1 Sept 2008

Ting Li-Min, Gissot Mathieu, Coppi Alida, Sinnis Photini, Kim Kami

Abstract excerpt

Malaria continues to devastate sub-Saharan Africa owing to the emergence of drug resistance to established antimalarials and to the lack of an efficacious vaccine. Plasmodium species have a unique streamlined purine pathway in which the dual specificity enzyme purine nucleoside phosphorylase (PNP) functions in both purine recycling and purine salvage. To evaluate the importance of PNP in an in vivo model of...

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Source

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Identifiers

PMID: 18758447
DOI: 10.1038/nm.1867
PMCID: PMC3937818

Genes

PNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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