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Article

Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.

The American journal of pathology - 1 Jan 2010

Spaccapelo Roberta, Janse Chris J, Caterbi Sara, Franke-Fayard Blandine, Bonilla J Alfredo, Syphard Luke M, Di Cristina Manlio, Dottorini Tania, Savarino Andrea, Cassone Antonio, Bistoni Francesco, Waters Andrew P, Dame John B, Crisanti Andrea

Abstract excerpt

Plasmodium parasites lacking plasmepsin 4 (PM4), an aspartic protease that functions in the lysosomal compartment and contributes to hemoglobin digestion, have only a modest decrease in the asexual blood-stage growth rate; however, PM4 deficiency in the rodent malaria parasite Plasmodium berghei...

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Identifiers

PMID: 20019192
DOI: 10.2353/ajpath.2010.090504
PMCID: PMC2797883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20019192-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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