Article
Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria.
The American journal of pathology - 1 Jan 2010
Spaccapelo Roberta, Janse Chris J, Caterbi Sara, Franke-Fayard Blandine, Bonilla J Alfredo, Syphard Luke M, Di Cristina Manlio, Dottorini Tania, Savarino Andrea, Cassone Antonio, Bistoni Francesco, Waters Andrew P, Dame John B, Crisanti Andrea
Abstract excerpt
Plasmodium parasites lacking plasmepsin 4 (PM4), an aspartic protease that functions in the lysosomal compartment and contributes to hemoglobin digestion, have only a modest decrease in the asexual blood-stage growth rate; however, PM4 deficiency in the rodent malaria parasite Plasmodium berghei results in significantly less virulence than that for the parental parasite. P. berghei Deltapm4 parasites failed to...
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